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Rett Syndrome has four stages.
Stage 1: Early Onset
This stage begins between 6 and 18 months and is often overlooked. Symptoms are characterized as a subtle lag in development. Infants may show less eye contact and interest in toys. They may also have delayed gross motor skills.
Stage 2: Rapid Destructive
This stage begins between 1 and 4 years and persists for multiple weeks or months, progressing either rapidly or gradually. Characteristic hand movements, such as wringing, clapping, or tapping emerge. Some children also move their hands to their mouths repeatedly or clasp them behind their backs. Breathing may also be irregular in the form of both apnea and hyperventilation. Symptoms may mimic autism in some children, as they have reduced social interaction and communication. Gross motor skills and head growth are also delayed.
Stage 3: Plateau
This stage occurs between 2 and 10 years and may last for several years or the rest of their lives. Problems with motor skills and seizures are prevalent during this stage, though children may become have improved behavior and less irritability. Children in this stage may also become more alert and attentive as well as showing more interest in her surroundings.
Stage 4: Late Motor Deterioration
This stage may last for several years or the rest of their lives. The muscles become weak, rigid, or spastic. This may make it difficult or impossible for them to walk. Children may also have scoliosis. Communication and cognition usually remain constant and gaze fixation may improve.
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